1YSI

Solution structure of the anti-apoptotic protein Bcl-xL in complex with an acyl-sulfonamide-based ligand

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Apoptosis regulator Bcl-X	polymer	181	20804.9	1	UniProt (Q07817) Pfam (PF02180) Pfam (PF00452)	Homo sapiens (human)	Bcl-2-like 1 protein
2	B (A)	N-[(4'-FLUORO-1,1'-BIPHENYL-4-YL)CARBONYL]-3-NITRO-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE	non-polymer		551.6	1	Chemie (N3B)

Sequence modifications

A: 5 - 48 (UniProt: Q07817)

PDB	External Database	Details
Met 1	-	expression tag
Ser 2	-	expression tag
Met 3	-	expression tag
Ala 4	-	expression tag
Leu 214	-	expression tag
Glu 215	-	expression tag
His 216	-	expression tag
His 217	-	expression tag
His 218	-	expression tag
His 219	-	expression tag
His 220	-	expression tag

A: 89 - 213 (UniProt: Q07817)

PDB	External Database	Details
His 181	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	20804.9
Non-Polymers*	Number of molecules	1
	Total formula weight	551.6
All*	Total formula weight	21356.5

*Water molecules are not included.