1YI2
Crystal Structure Of Erythromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (0) | 23S Ribosomal RNA | polymer | 2922 | 946141.4 | 1 | GenBank (55229667) | Haloarcula marismortui | |
| 2 | B (9) | 5S Ribosomal RNA | polymer | 122 | 39303.4 | 1 | GenBank (3377778) | Haloarcula marismortui | |
| 3 | C (A) | 50S ribosomal protein L2P | polymer | 240 | 25354.7 | 1 | UniProt (P20276) Pfam (PF00181) Pfam (PF03947) | Haloarcula marismortui | |
| 4 | D (B) | 50S ribosomal protein L3P | polymer | 338 | 37396.4 | 1 | GenBank (55378384) Pfam (PF00297) UniProt (by SIFTS) (P20279) | Haloarcula marismortui | |
| 5 | E (C) | 50S ribosomal protein L4E | polymer | 246 | 26442.1 | 1 | UniProt (P12735) Pfam (PF00573) | Haloarcula marismortui | |
| 6 | F (D) | 50S ribosomal protein L5P | polymer | 177 | 19551.7 | 1 | UniProt (P14124) Pfam (PF00281) Pfam (PF00673) | Haloarcula marismortui | |
| 7 | G (E) | 50S ribosomal protein L6P | polymer | 178 | 19961.7 | 1 | UniProt (P14135) Pfam (PF00347) | Haloarcula marismortui | |
| 8 | H (F) | 50S ribosomal protein L7AE | polymer | 120 | 12791.9 | 1 | UniProt (P12743) Pfam (PF01248) | Haloarcula marismortui | |
| 9 | I (G) | ACIDIC RIBOSOMAL PROTEIN P0 HOMOLOG | polymer | 348 | 37213.8 | 1 | UniProt (P15825) Pfam (PF00466) Pfam (PF17777) | Haloarcula marismortui | |
| 10 | J (H) | 50S RIBOSOMAL PROTEIN L10E | polymer | 177 | 19942.7 | 1 | GenBank (55231756) Pfam (PF00252) UniProt (by SIFTS) (P60617) | Haloarcula marismortui | |
| 11 | K (I) | 50S RIBOSOMAL PROTEIN L11P | polymer | 162 | 17097.5 | 1 | GenBank (132647) Pfam (PF03946) Pfam (PF00298) UniProt (by SIFTS) (P14122) | Haloarcula marismortui | |
| 12 | L (J) | 50S ribosomal protein L13P | polymer | 145 | 16249.2 | 1 | UniProt (P29198) Pfam (PF00572) | Haloarcula marismortui | |
| 13 | M (K) | 50S ribosomal protein L14P | polymer | 132 | 14191.2 | 1 | UniProt (P22450) Pfam (PF00238) | Haloarcula marismortui | |
| 14 | N (L) | 50S ribosomal protein L15P | polymer | 165 | 18005.4 | 1 | UniProt (P12737) Pfam (PF00828) | Haloarcula marismortui | |
| 15 | O (M) | 50S Ribosomal Protein L15E | polymer | 195 | 22275.1 | 1 | GenBank (55231501) Pfam (PF00827) UniProt (by SIFTS) (P60618) | Haloarcula marismortui | |
| 16 | P (N) | 50S ribosomal protein L18P | polymer | 187 | 20640.9 | 1 | UniProt (P14123) Pfam (PF17144) | Haloarcula marismortui | |
| 17 | Q (O) | 50S ribosomal protein L18e | polymer | 116 | 12438.9 | 1 | UniProt (P12733) Pfam (PF00828) | Haloarcula marismortui | |
| 18 | R (P) | 50S ribosomal protein L19E | polymer | 149 | 16796.5 | 1 | UniProt (P14119) Pfam (PF01280) Pfam (PF25476) | Haloarcula marismortui | |
| 19 | S (Q) | 50S ribosomal protein L21e | polymer | 96 | 10567.8 | 1 | UniProt (P12734) Pfam (PF01157) | Haloarcula marismortui | |
| 20 | T (R) | 50S ribosomal protein L22P | polymer | 155 | 16966.9 | 1 | UniProt (P10970) Pfam (PF00237) | Haloarcula marismortui | |
| 21 | U (S) | 50S ribosomal protein L23P | polymer | 85 | 9612.5 | 1 | UniProt (P12732) Pfam (PF00276) | Haloarcula marismortui | |
| 22 | V (T) | 50S ribosomal protein L24P | polymer | 120 | 13671.0 | 1 | UniProt (P10972) Pfam (PF16906) Pfam (PF00467) | Haloarcula marismortui | |
| 23 | W (U) | 50S ribosomal protein L24E | polymer | 66 | 7233.7 | 1 | UniProt (P14116) Pfam (PF01246) | Haloarcula marismortui | |
| 24 | X (V) | 50S ribosomal protein L29P | polymer | 71 | 7889.9 | 1 | UniProt (P10971) Pfam (PF00831) | Haloarcula marismortui | |
| 25 | Y (W) | 50S ribosomal protein L30P | polymer | 154 | 17062.9 | 1 | UniProt (P14121) Pfam (PF00327) | Haloarcula marismortui | |
| 26 | Z (X) | 50S ribosomal protein L31e | polymer | 92 | 10384.6 | 1 | UniProt (P18138) Pfam (PF01198) | Haloarcula marismortui | |
| 27 | AA (Y) | 50S ribosomal protein L32E | polymer | 241 | 26455.7 | 1 | UniProt (P12736) Pfam (PF14520) Pfam (PF01655) | Haloarcula marismortui | |
| 28 | BA (Z) | 50S ribosomal protein L37Ae | polymer | 83 | 9409.3 | 1 | GenBank (55231162) Pfam (PF01780) UniProt (by SIFTS) (P60619) | Haloarcula marismortui | |
| 29 | CA (1) | 50S ribosomal protein L37e | polymer | 57 | 6330.2 | 1 | UniProt (P32410) Pfam (PF01907) | Haloarcula marismortui | |
| 30 | DA (2) | 50S ribosomal protein L39e | polymer | 50 | 6133.1 | 1 | UniProt (P22452) Pfam (PF00832) | Haloarcula marismortui | |
| 31 | EA (3) | 50S ribosomal protein L44E | polymer | 92 | 10815.2 | 1 | UniProt (P32411) Pfam (PF00935) | Haloarcula marismortui | |
| 32 | FA (0) | ERYTHROMYCIN A | non-polymer | 733.9 | 1 | Chemie (ERY) PubChem (16219331) PubChem (16757675) PubChem (12560) PubChem (22489166) PubChem (22836457) PubChem (22836628) PubChem (23229191) PubChem (24797108) PubChem (16219337) PubChem (16401342) PubChem (16759276) PubChem (18397931) PubChem (18528813) PubChem (21550772) PubChem (22836626) PubChem (44451949) PubChem (45107170) PubChem (45107190) PubChem (45107269) PubChem (45107273) PubChem (44317775) PubChem (44547821) PubChem (44563509) PubChem (49867933) PubChem (51066560) PubChem (45107581) PubChem (53384904) PubChem (53384913) PubChem (57358551) PubChem (50987679) PubChem (57587180) PubChem (53393685) PubChem (54359201) PubChem (59974395) PubChem (60044171) PubChem (60086513) PubChem (57357418) PubChem (66577477) PubChem (57893297) PubChem (58594795) PubChem (58593559) PubChem (59022390) PubChem (59062422) PubChem (59064284) PubChem (59093569) PubChem (59284311) PubChem (59511080) PubChem (59897430) PubChem (59903654) PubChem (60009793) PubChem (60024420) PubChem (66639443) PubChem (66899541) PubChem (71024089) PubChem (177390461) PubChem (177679009) PubChem (6364614) PubChem (3255) PubChem (8233) PubChem (9361) PubChem (6604684) PubChem (6713919) PubChem (154401) PubChem (89970519) PubChem (70897564) PubChem (71306958) PubChem (90472408) PubChem (73265320) PubChem (73456721) PubChem (73946784) PubChem (456593) PubChem (467795) PubChem (489009) PubChem (10034134) PubChem (86820632) PubChem (90473776) PubChem (90746906) PubChem (12358509) PubChem (12358517) PubChem (12966969) PubChem (97293607) PubChem (91434318) PubChem (91558259) PubChem (15986867) PubChem (99719272) PubChem (97293608) PubChem (99719271) PubChem (110189186) PubChem (6540620) PubChem (6602506) PubChem (6604221) PubChem (124226124) PubChem (124518166) PubChem (124604978) PubChem (124605145) PubChem (124605175) PubChem (124723146) PubChem (124798369) PubChem (124762348) PubChem (124822557) PubChem (9833120) PubChem (10032882) PubChem (129009922) PubChem (129125718) PubChem (129445574) PubChem (129445576) PubChem (129666958) PubChem (10897911) PubChem (132274086) PubChem (133126690) PubChem (133126790) PubChem (133550114) PubChem (133688268) PubChem (134081643) PubChem (134081274) PubChem (134693955) PubChem (118725304) PubChem (11970254) PubChem (124226125) PubChem (124523502) PubChem (124604979) PubChem (124605144) PubChem (124605146) PubChem (124716782) PubChem (124716783) PubChem (124723147) PubChem (124762349) PubChem (12358519) PubChem (12358515) PubChem (12358508) PubChem (124822555) PubChem (124822558) PubChem (124870987) PubChem (137705094) PubChem (126969058) PubChem (129010384) PubChem (129119817) PubChem (129445575) PubChem (139247122) PubChem (129627840) PubChem (129628729) PubChem (131665174) PubChem (141945645) PubChem (133562871) PubChem (133602826) PubChem (146158524) PubChem (134081264) PubChem (134693174) PubChem (135026875) PubChem (157254288) PubChem (163003493) PubChem (163003495) PubChem (138113460) PubChem (138403276) PubChem (165844830) PubChem (140886742) PubChem (141646830) PubChem (145774355) PubChem (169440260) PubChem (155899868) PubChem (155900413) PubChem (172897573) PubChem (161123720) PubChem (163003494) PubChem (163003496) PubChem (166604455) PubChem (166639762) PubChem (169289157) PubChem (171114703) PubChem (172897571) PubChem (16212992) PubChem (16213052) | |||
| 33 | AB, AC, AD, AE, AJ... (0, 3, K, 9, A...) | MAGNESIUM ION | non-polymer | 24.3 | 116 | Chemie (MG) PubChem (888) | |||
| 34 | KE, LE (0) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) PubChem (813) | |||
| 35 | AF, AG, AH, AI, BF... (0, J, L, M, Q...) | SODIUM ION | non-polymer | 23.0 | 86 | Chemie (NA) PubChem (923) | |||
| 36 | BI, CI, CJ, DI, FH... (J, 3, 0, L, M...) | CHLORIDE ION | non-polymer | 35.5 | 22 | Chemie (CL) PubChem (312) | |||
| 37 | BJ, KI, UI, XI, YI (3, O, U, Z, 1) | CADMIUM ION | non-polymer | 112.4 | 5 | Chemie (CD) PubChem (31193) | |||
| 38 | AK, BK, CK, DJ, DK... (V, W, X, 0, Y...) | water | water | 18.0 | 7808 | Chemie (HOH) |
Sequence modifications
0: 1 - 2922 (GenBank: 55229667)
K: 1 - 132 (UniProt: P22450)
M: 0 - 194 (GenBank: 55231501)
Z: 10 - 92 (GenBank: 55231162)
| PDB | External Database | Details |
|---|---|---|
| 1ma 628 | A 627 | modified residue |
| A 2099 | G 2098 | engineered mutation |
| Omu 2587 | U 2586 | modified residue |
| Omg 2588 | G 2587 | modified residue |
| Ur3 2619 | U 2618 | modified residue |
| Psu 2621 | U 2620 | modified residue |
| PDB | External Database | Details |
|---|---|---|
| Leu 44 | His 44 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Glu 13 | Lys 14 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 10 | Ser 34 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 31 |
| Total formula weight | 1474327.6 | |
| Non-Polymers* | Number of molecules | 232 |
| Total formula weight | 6950.7 | |
| All* | Total formula weight | 1481278.2 |
