1Y8X
Structural basis for recruitment of Ubc12 by an E2-binding domain in NEDD8's E1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Ubiquitin-conjugating enzyme E2 M | polymer | 160 | 18485.6 | 1 | UniProt (P61081) Pfam (PF00179) | Homo sapiens (human) | Ubiquitin-protein ligase M, Ubiquitin carrier protein M, Nedd8-conjugating enzyme Ubc12 |
| 2 | B (B) | Ubiquitin-activating enzyme E1C | polymer | 98 | 10857.0 | 1 | UniProt (Q8TBC4) Pfam (PF08825) | Homo sapiens (human) | Nedd8-activating enzyme E1C, Ubiquitin-activating enzyme 3 homolog |
| 3 | C, D (A, B) | water | water | 18.0 | 112 | Chemie (HOH) |
Sequence modifications
A: 27 - 183 (UniProt: P61081)
B: 347 - 442 (UniProt: Q8TBC4)
| PDB | External Database | Details |
|---|---|---|
| Gly 24 | - | cloning artifact |
| Ser 25 | - | cloning artifact |
| Mse 26 | - | cloning artifact |
| Mse 98 | Met 98 | modified residue |
| Mse 168 | Met 168 | modified residue |
| PDB | External Database | Details |
|---|---|---|
| Gly 345 | - | cloning artifact |
| Ser 346 | - | cloning artifact |
| Mse 376 | Met 397 | modified residue |
| Mse 394 | Leu 415 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29342.6 | |
| All* | Total formula weight | 29342.6 |
