1Y6N
Crystal structure of Epstein-Barr virus IL-10 mutant (A87I) complexed with the soluble IL-10R1 chain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Viral interleukin-10 homolog | polymer | 145 | 17439.3 | 1 | UniProt (P03180) Pfam (PF00726) | Human herpesvirus 4 (Epstein-Barr virus) | vIL-10, BCRF1 protein, 20 kDa protein |
| 2 | B (R) | Interleukin-10 receptor alpha chain | polymer | 214 | 24506.6 | 1 | UniProt (Q13651) Pfam (PF01108) | Homo sapiens (human) | IL-10R-A, IL-10R1 |
| 3 | C, D (L, R) | water | water | 18.0 | 41 | Chemie (HOH) |
Sequence modifications
L: 12 - 159 (UniProt: P03180)
R: 1 - 214 (UniProt: Q13651)
| PDB | External Database | Details |
|---|---|---|
| Mse 22 | Met 33 | modified residue |
| Mse 68 | Met 79 | modified residue |
| Mse 77 | Met 88 | modified residue |
| Ile 87 | Ala 98 | engineered mutation |
| Mse 140 | Met 151 | modified residue |
| Mse 154 | Met 165 | modified residue |
| PDB | External Database | Details |
|---|---|---|
| Gln 29 | Asn 50 | engineered mutation |
| Gln 53 | Asn 74 | engineered mutation |
| Gln 89 | Asn 110 | engineered mutation |
| Gln 133 | Asn 154 | engineered mutation |
| Gln 156 | Asn 177 | engineered mutation |
| Gln 168 | Asn 189 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 41945.8 | |
| All* | Total formula weight | 41945.8 |
