1Y6N

Crystal structure of Epstein-Barr virus IL-10 mutant (A87I) complexed with the soluble IL-10R1 chain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	L	Viral interleukin-10 homolog	polymer	145	17439.3	1	UniProt (P03180) Pfam (PF00726) In PDB	Human herpesvirus 4 (Epstein-Barr virus)	vIL-10, BCRF1 protein, 20 kDa protein
2	R	Interleukin-10 receptor alpha chain	polymer	214	24506.6	1	UniProt (Q13651) Pfam (PF01108) In PDB	Homo sapiens (human)	IL-10R-A, IL-10R1
3		water	water		18.0	41	Chemie (HOH)

Sequence modifications

L: 12 - 159 (UniProt: P03180)

PDB	External Database	Details
Mse 22	Met 33	modified residue
Mse 68	Met 79	modified residue
Mse 77	Met 88	modified residue
Ile 87	Ala 98	engineered mutation
Mse 140	Met 151	modified residue
Mse 154	Met 165	modified residue

R: 1 - 214 (UniProt: Q13651)

PDB	External Database	Details
Gln 29	Asn 50	engineered mutation
Gln 53	Asn 74	engineered mutation
Gln 89	Asn 110	engineered mutation
Gln 133	Asn 154	engineered mutation
Gln 156	Asn 177	engineered mutation
Gln 168	Asn 189	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	41945.8
All*	Total formula weight	41945.8

*Water molecules are not included.