1Y2H
Catalytic Domain Of Human Phosphodiesterase 4B In Complex With 1-(2-chloro-phenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | polymer | 398 | 45731.3 | 2 | UniProt (Q07343) Pfam (PF00233) | Homo sapiens (human) | DPDE4, PDE32 |
| 2 | C, F (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, G (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E, H (A, B) | 1-(2-CHLOROPHENYL)-3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | non-polymer | 278.7 | 2 | Chemie (6DE) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 44 | Chemie (HOH) |
Sequence modifications
A, B: 152 - 528 (UniProt: Q07343)
| PDB | External Database | Details |
|---|---|---|
| Met 131 | - | initiating methionine |
| Gly 132 | - | cloning artifact |
| Ser 133 | - | cloning artifact |
| Ser 134 | - | cloning artifact |
| His 135 | - | expression tag |
| His 136 | - | expression tag |
| His 137 | - | expression tag |
| His 138 | - | expression tag |
| His 139 | - | expression tag |
| His 140 | - | expression tag |
| Ser 141 | - | cloning artifact |
| Ser 142 | - | cloning artifact |
| Gly 143 | - | cloning artifact |
| Leu 144 | - | cloning artifact |
| Val 145 | - | cloning artifact |
| Pro 146 | - | cloning artifact |
| Arg 147 | - | cloning artifact |
| Gly 148 | - | cloning artifact |
| Ser 149 | - | cloning artifact |
| His 150 | - | cloning artifact |
| Met 151 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 91462.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 736.9 | |
| All* | Total formula weight | 92199.6 |
