1XXF

Crystal Structure of the FXIa Catalytic Domain in Complex with Ecotin Mutant (EcotinP)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Coagulation factor XI	polymer	238	26826.5	2	UniProt (P03951) Pfam (PF00089)	Homo sapiens (human)	Plasma thromboplastin antecedent; PTA; FXI
2	C, D (C, D)	Ecotin	polymer	142	16218.5	2	UniProt (P23827) Pfam (PF03974)	Escherichia coli
3	E, F (B)	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
4	G, H, I, J (A, B, C, D)	water	water		18.0	123	Chemie (HOH)

Sequence modifications

A, B: 16 - 245 (UniProt: P03951)

PDB	External Database	Details
Ala 56	Ser 452	engineered mutation
Ala 97	Thr 493	engineered mutation

C, D: 1 - 142 (UniProt: P23827)

PDB	External Database	Details
Asp 81	Val 101	engineered mutation
Phe 82	Ser 102	engineered mutation
Arg 84	Met 104	engineered mutation
Val 85	Met 105	engineered mutation
Val 86	Ala 106	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	86090.2
Non-Polymers*	Number of molecules	2
	Total formula weight	46.0
All*	Total formula weight	86136.1

*Water molecules are not included.