1XX9
Crystal Structure of the FXIa Catalytic Domain in Complex with EcotinM84R
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Coagulation factor XI | polymer | 238 | 26872.6 | 2 | UniProt (P03951) Pfam (PF00089) | Homo sapiens (human) | Plasma thromboplastin antecedent; PTA; FXI |
| 2 | C, D (C, D) | Ecotin | polymer | 142 | 16146.5 | 2 | UniProt (P23827) Pfam (PF03974) | Escherichia coli | |
| 3 | E (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 4 | F, G, H, I (A, B, C, D) | water | water | 18.0 | 260 | Chemie (HOH) |
Sequence modifications
C, D: 1 - 142 (UniProt: P23827)
| PDB | External Database | Details |
|---|---|---|
| Arg 84 | Met 104 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 86038.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 86259.3 |
