1XU9
Crystal Structure of the Interface Closed Conformation of 11b-hydroxysteroid dehydrogenase isozyme 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Corticosteroid 11-beta-dehydrogenase, isozyme 1 | polymer | 286 | 31836.9 | 4 | UniProt (P28845) Pfam (PF00106) In PDB | Homo sapiens (human) | 11-DH, 11-beta-hydroxysteroid dehydrogenase 1, 11-beta-HSD1 |
| 2 | A, B, C, D | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 4 | Chemie (NDP) | |||
| 3 | A, B, C, D | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE | non-polymer | 614.9 | 4 | Chemie (CPS) | |||
| 4 | A | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 5 | water | water | 18.0 | 1259 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 24 - 292 (UniProt: P28845)
| PDB | External Database | Details |
|---|---|---|
| Met 7 | - | initiating methionine |
| Lys 8 | - | cloning artifact |
| His 9 | - | cloning artifact |
| Gln 10 | - | cloning artifact |
| His 11 | - | cloning artifact |
| Gln 12 | - | cloning artifact |
| His 13 | - | cloning artifact |
| Gln 14 | - | cloning artifact |
| His 15 | - | cloning artifact |
| Gln 16 | - | cloning artifact |
| His 17 | - | cloning artifact |
| Gln 18 | - | cloning artifact |
| His 19 | - | cloning artifact |
| Gln 20 | - | cloning artifact |
| Gln 21 | - | cloning artifact |
| Pro 22 | - | cloning artifact |
| Leu 23 | - | cloning artifact |
| Ser 272 | Cys 272 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 127347.5 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 5636.4 | |
| All* | Total formula weight | 132983.9 |
