1XU9
Crystal Structure of the Interface Closed Conformation of 11b-hydroxysteroid dehydrogenase isozyme 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Corticosteroid 11-beta-dehydrogenase, isozyme 1 | polymer | 286 | 31836.9 | 4 | UniProt (P28845) Pfam (PF00106) | Homo sapiens (human) | 11-DH, 11-beta-hydroxysteroid dehydrogenase 1, 11-beta-HSD1 |
| 2 | E, H, J, L (A, B, C, D) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 4 | Chemie (NDP) | |||
| 3 | F, I, K, M (A, B, C, D) | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE | non-polymer | 614.9 | 4 | Chemie (CPS) PubChem (16396400) PubChem (18397788) PubChem (177530666) PubChem (24883538) PubChem (457060) PubChem (44120060) PubChem (44450441) PubChem (50987450) PubChem (51028881) PubChem (51028882) PubChem (53393728) PubChem (3659871) PubChem (58528211) PubChem (53229977) PubChem (107670) PubChem (71774074) PubChem (9895216) PubChem (10371606) PubChem (90488808) PubChem (91746229) PubChem (91809267) PubChem (102565428) PubChem (122361936) PubChem (122362044) PubChem (131632459) PubChem (133645855) PubChem (137704711) PubChem (146159681) | |||
| 4 | G (A) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) PubChem (4478249) | |||
| 5 | N, O, P, Q (A, B, C, D) | water | water | 18.0 | 1259 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 24 - 292 (UniProt: P28845)
| PDB | External Database | Details |
|---|---|---|
| Met 7 | - | initiating methionine |
| Lys 8 | - | cloning artifact |
| His 9 | - | cloning artifact |
| Gln 10 | - | cloning artifact |
| His 11 | - | cloning artifact |
| Gln 12 | - | cloning artifact |
| His 13 | - | cloning artifact |
| Gln 14 | - | cloning artifact |
| His 15 | - | cloning artifact |
| Gln 16 | - | cloning artifact |
| His 17 | - | cloning artifact |
| Gln 18 | - | cloning artifact |
| His 19 | - | cloning artifact |
| Gln 20 | - | cloning artifact |
| Gln 21 | - | cloning artifact |
| Pro 22 | - | cloning artifact |
| Leu 23 | - | cloning artifact |
| Ser 272 | Cys 272 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 127347.5 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 5636.4 | |
| All* | Total formula weight | 132983.9 |
