1XP0
Catalytic Domain Of Human Phosphodiesterase 5A In Complex With Vardenafil
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | cGMP-specific 3',5'-cyclic phosphodiesterase | polymer | 364 | 41827.9 | 1 | UniProt (O76074) Pfam (PF00233) | Homo sapiens (human) | CGB-PDE, cGMP-binding cGMP-specific phosphodiesterase, PDE5A |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (A) | 2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE | non-polymer | 488.6 | 1 | Chemie (VDN) | |||
| 5 | E (A) | water | water | 18.0 | 156 | Chemie (HOH) |
Sequence modifications
A: 534 - 875 (UniProt: O76074)
| PDB | External Database | Details |
|---|---|---|
| Met 513 | - | initiating methionine |
| Gly 514 | - | cloning artifact |
| Ser 515 | - | cloning artifact |
| Ser 516 | - | cloning artifact |
| His 517 | - | expression tag |
| His 518 | - | expression tag |
| His 519 | - | expression tag |
| His 520 | - | expression tag |
| His 521 | - | expression tag |
| His 522 | - | expression tag |
| Ser 523 | - | cloning artifact |
| Ser 524 | - | cloning artifact |
| Gly 525 | - | cloning artifact |
| Leu 526 | - | cloning artifact |
| Val 527 | - | cloning artifact |
| Pro 528 | - | cloning artifact |
| Arg 529 | - | cloning artifact |
| Gly 530 | - | cloning artifact |
| Ser 531 | - | cloning artifact |
| His 532 | - | cloning artifact |
| Met 533 | - | cloning artifact |
| Pro 658 | Arg 658 | engineered mutation |
| Ser 661 | Asn 661 | engineered mutation |
| Gln 663 | Asn 663 | engineered mutation |
| Leu 647 | Ser 664 | engineered mutation |
| Ile 648 | Tyr 665 | engineered mutation |
| Asn 667 | Arg 667 | engineered mutation |
| Thr 668 | Ser 668 | engineered mutation |
| Asn 669 | Glu 669 | engineered mutation |
| Ser 670 | His 670 | engineered mutation |
| Glu 671 | Pro 671 | engineered mutation |
| Leu 674 | Gln 674 | engineered mutation |
| Met 675 | Leu 675 | engineered mutation |
| Asn 676 | Cys 677 | engineered mutation |
| Asp 677 | - | engineered mutation |
| Glu 678 | His 678 | engineered mutation |
| Val 680 | Ile 680 | engineered mutation |
| Leu 681 | Met 681 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41827.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 578.3 | |
| All* | Total formula weight | 42406.3 |
