1XOT
Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Vardenafil
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B, A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | polymer | 398 | 45731.3 | 2 | UniProt (Q07343) Pfam (PF00233) In PDB | Homo sapiens (human) | DPDE4, PDE32 |
| 2 | B, A | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | B, A | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | B, A | 2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE | non-polymer | 488.6 | 2 | Chemie (VDN) | |||
| 5 | water | water | 18.0 | 46 | Chemie (HOH) |
Sequence modifications
B, A: 152 - 528 (UniProt: Q07343)
| PDB | External Database | Details |
|---|---|---|
| Met 131 | - | INITIATING METHIONINE |
| Gly 132 | - | CLONING ARTIFACT |
| Ser 133 | - | CLONING ARTIFACT |
| Ser 134 | - | CLONING ARTIFACT |
| His 135 | - | EXPRESSION TAG |
| His 136 | - | EXPRESSION TAG |
| His 137 | - | EXPRESSION TAG |
| His 138 | - | EXPRESSION TAG |
| His 139 | - | EXPRESSION TAG |
| His 140 | - | EXPRESSION TAG |
| Ser 141 | - | CLONING ARTIFACT |
| Ser 142 | - | CLONING ARTIFACT |
| Gly 143 | - | CLONING ARTIFACT |
| Leu 144 | - | CLONING ARTIFACT |
| Val 145 | - | CLONING ARTIFACT |
| Pro 146 | - | CLONING ARTIFACT |
| Arg 147 | - | CLONING ARTIFACT |
| Gly 148 | - | CLONING ARTIFACT |
| Ser 149 | - | CLONING ARTIFACT |
| His 150 | - | CLONING ARTIFACT |
| Met 151 | - | CLONING ARTIFACT |
| Cme 194 | Cys 366 | MODIFIED RESIDUE |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 91462.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1156.6 | |
| All* | Total formula weight | 92619.3 |
