1XMJ
Crystal structure of human deltaF508 human NBD1 domain with ATP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cystic fibrosis transmembrane conductance regulator | polymer | 290 | 32353.8 | 1 | UniProt (P13569) Pfam (PF00005) | Homo sapiens (human) | CFTR; cAMP- dependent chloride channel |
| 2 | B (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 3 | C (A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 4 | D (A) | water | water | 18.0 | 135 | Chemie (HOH) |
Sequence modifications
A: 388 - 677 (UniProt: P13569)
| PDB | External Database | Details |
|---|---|---|
| Ser 388 | Thr 388 | cloning artifact |
| Leu 409 | Phe 409 | engineered mutation |
| Ser 429 | Phe 429 | engineered mutation |
| Leu 433 | Phe 433 | engineered mutation |
| - | Phe 508 | deletion |
| Glu 550 | Gly 550 | engineered mutation |
| Gln 552 | Arg 553 | engineered mutation |
| Lys 555 | Arg 555 | engineered mutation |
| Arg 667 | His 667 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32353.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 531.5 | |
| All* | Total formula weight | 32885.3 |
