1XMI
Crystal structure of human F508A NBD1 domain with ATP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Cystic fibrosis transmembrane conductance regulator | polymer | 291 | 32477.9 | 5 | UniProt (P13569) Pfam (PF00005) | Homo sapiens (human) | CFTR; cAMP- dependent chloride channel |
| 2 | F, H, J, L, N (A, B, C, D, E) | MAGNESIUM ION | non-polymer | 24.3 | 5 | Chemie (MG) | |||
| 3 | G, I, K, M, O (A, B, C, D, E) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 5 | Chemie (ATP) | |||
| 4 | P, Q, R, S, T (A, B, C, D, E) | water | water | 18.0 | 704 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 388 - 678 (UniProt: P13569)
| PDB | External Database | Details |
|---|---|---|
| Ser 388 | Thr 388 | cloning artifact |
| Ser 429 | Phe 429 | engineered mutation |
| Ala 508 | Phe 508 | engineered mutation |
| Arg 667 | His 667 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 162389.4 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2657.4 | |
| All* | Total formula weight | 165046.9 |
