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1XM6

Catalytic Domain Of Human Phosphodiesterase 4B In Complex With (R)-Mesopram

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BcAMP-specific 3',5'-cyclic phosphodiesterase 4Bpolymer39845883.62UniProt (Q07343)
Pfam (PF00233)
In PDB
Homo sapiens (human)DPDE4, PDE32
2A, BZINC IONnon-polymer65.42Chemie (ZN)
3A, BMAGNESIUM IONnon-polymer24.32Chemie (MG)
4A, B(5R)-5-(4-methoxy-3-propoxyphenyl)-5-methyl-1,3-oxazolidin-2-onenon-polymer265.32Chemie (5RM)
5waterwater18.0224Chemie (HOH)
Sequence modifications
A, B: 152 - 528 (UniProt: Q07343)
PDBExternal DatabaseDetails
Met 131-INITIATING METHIONINE
Gly 132-CLONING ARTIFACT
Ser 133-CLONING ARTIFACT
Ser 134-CLONING ARTIFACT
His 135-EXPRESSION TAG
His 136-EXPRESSION TAG
His 137-EXPRESSION TAG
His 138-EXPRESSION TAG
His 139-EXPRESSION TAG
His 140-EXPRESSION TAG
Ser 141-CLONING ARTIFACT
Ser 142-CLONING ARTIFACT
Gly 143-CLONING ARTIFACT
Leu 144-CLONING ARTIFACT
Val 145-CLONING ARTIFACT
Pro 146-CLONING ARTIFACT
Arg 147-CLONING ARTIFACT
Gly 148-CLONING ARTIFACT
Ser 149-CLONING ARTIFACT
His 150-CLONING ARTIFACT
Met 151-CLONING ARTIFACT
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight91767.1
Non-Polymers*Number of molecules6
Total formula weight710.0
All*Total formula weight92477.2
*Water molecules are not included.

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PDB entries from 2024-07-10

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