1XIW

Crystal structure of human CD3-e/d dimer in complex with a UCHT1 single-chain antibody fragment

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E (A, E)	T-cell surface glycoprotein CD3 epsilon chain	polymer	105	11893.1	2	UniProt (P07766) Pfam (PF16681)	Homo sapiens (human)	T-cell surface antigen T3/Leu-4 epsilon chain
2	B, F (B, F)	T-cell surface glycoprotein CD3 delta chain	polymer	79	9106.4	2	UniProt (P04234) Pfam (PF16680)	Homo sapiens (human)	T-cell receptor T3 delta chain
3	C, G (C, G)	immunoglobulin light chain variable region	polymer	108	11994.3	2	PIR (PH0888)	Mus musculus (house mouse)
4	D, H (D, H)	immunoglobulin heavy chain variable region	polymer	122	13650.2	2	PIR (PH0887)	Mus musculus (house mouse)
5	I, J, K, L, M... (A, B, C, D, E...)	water	water		18.0	319	Chemie (HOH)

Sequence modifications

A, E: 2 - 105 (UniProt: P07766)

PDB	External Database	Details
Met 1	-	initiating methionine

B, F: 2 - 79 (UniProt: P04234)

PDB	External Database	Details
Met 1	-	initiating methionine

C, G: 2 - 108 (PIR: PH0888)

PDB	External Database	Details
Met 1	-	initiating methionine

D, H: 1 - 122 (PIR: PH0887)

PDB	External Database	Details
Leu 70	Phe 70	SEE REMARK 999
Gln 114	Ala 114	SEE REMARK 999
Leu 118	Val 118	SEE REMARK 999
Phe 121	Ser 121	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	93288.1
All*	Total formula weight	93288.1

*Water molecules are not included.