1XH4
Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | cAMP-dependent protein kinase, alpha-catalytic subunit | polymer | 350 | 40786.4 | 1 | UniProt (P00517) Pfam (PF00069) In PDB | Bos taurus (cattle) | Protein Kinase A, PKA C-alpha |
| 2 | B | cAMP-dependent protein kinase inhibitor, alpha form | polymer | 20 | 2226.4 | 1 | UniProt (P61925) In PDB | Protein Kinase Inhibitor Peptide; PKI-alpha; cAMP-dependent protein kinase inhibitor, muscle/brain isoform | |
| 3 | A | N-[4-({4-[5-(DIMETHYLAMINO)-2-HYDROXYBENZOYL]BENZOYL}AMINO)AZEPAN-3-YL]ISONICOTINAMIDE | non-polymer | 501.6 | 1 | Chemie (R69) | |||
| 4 | water | water | 18.0 | 115 | Chemie (HOH) |
Sequence modifications
A: 1 - 350 (UniProt: P00517)
| PDB | External Database | Details |
|---|---|---|
| Sep 139 | Ser 139 | MODIFIED RESIDUE |
| Tpo 197 | Thr 197 | MODIFIED RESIDUE |
| Sep 338 | Ser 338 | MODIFIED RESIDUE |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43012.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 501.6 | |
| All* | Total formula weight | 43514.4 |
