1XFW
Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3'5' cyclic AMP (cAMP)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Calmodulin-sensitive adenylate cyclase | polymer | 777 | 90128.9 | 6 | UniProt (P40136) Pfam (PF07737) Pfam (PF03497) Pfam (PF20850) | Bacillus anthracis | ATP pyrophosphate-lyase, Adenylyl cyclase, Edema factor, EF, Anthrax edema toxin adenylate cyclase component |
| 2 | G, H, I, J, K... (O, P, Q, R, S...) | Calmodulin 2 | polymer | 149 | 16851.6 | 6 | UniProt (P62158) Pfam (PF13499) UniProt (by SIFTS) (P0DP23) | Homo sapiens (human) | |
| 3 | M, O, Q, S, U... (A, B, C, D, E...) | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) PubChem (888) | |||
| 4 | N, P, R, T, V... (A, B, C, D, E...) | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE | non-polymer | 329.2 | 6 | Chemie (CMP) PubChem (176488666) PubChem (6076) PubChem (23902375) PubChem (25322948) PubChem (40467852) PubChem (44629928) PubChem (25322946) PubChem (56973690) PubChem (216878) PubChem (59909322) PubChem (59968988) PubChem (70878457) PubChem (59350541) PubChem (3080770) PubChem (3246347) PubChem (274) PubChem (6604194) PubChem (6603718) PubChem (6713792) PubChem (6714006) PubChem (124132380) PubChem (12071879) PubChem (12866365) PubChem (163043517) PubChem (129317551) PubChem (131841987) PubChem (134693155) PubChem (138107790) PubChem (163043518) | |||
| 5 | AA, BA, CA, DA, EA... (O, P, Q, R, S...) | CALCIUM ION | non-polymer | 40.1 | 18 | Chemie (CA) PubChem (271) | |||
| 6 | QA, RA, SA, TA, UA... (A, B, C, D, E...) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 33 - 800 (UniProt: P40136)
| PDB | External Database | Details |
|---|---|---|
| Met 24 | - | initiating methionine |
| His 25 | - | expression tag |
| His 26 | - | expression tag |
| His 27 | - | expression tag |
| His 28 | - | expression tag |
| His 29 | - | expression tag |
| His 30 | - | expression tag |
| Ala 31 | - | cloning artifact |
| Ala 32 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 641882.8 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 2842.5 | |
| All* | Total formula weight | 644725.2 |
