1XF1

Structure of C5a peptidase- a key virulence factor from Streptococcus

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	C5a peptidase	polymer	926	102996.1	2	UniProt (P15926) Pfam (PF00082) Pfam (PF02225) Pfam (PF06280) Pfam (PF13585) Pfam (PF22143)	Streptococcus pyogenes	SCP
2	C, H (A, B)	ACETATE ION	non-polymer		59.0	2	Chemie (ACT)
3	D, I (A, B)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
4	E, F, G, J, K... (A, B)	CITRIC ACID	non-polymer		192.1	6	Chemie (CIT)
5	M, N (A, B)	water	water		18.0	1057	Chemie (HOH)

Sequence modifications

A, B: 106 - 1031 (UniProt: P15926)

PDB	External Database	Details
Mse 219	Met 219	modified residue
Mse 227	Met 227	modified residue
Mse 259	Met 259	modified residue
Mse 353	Met 353	modified residue
Mse 433	Met 433	modified residue
Mse 513	Met 513	modified residue
Mse 522	Met 522	modified residue
Mse 536	Met 536	modified residue
Mse 550	Met 550	modified residue
Mse 585	Met 585	modified residue
Thr 648	Ala 648	SEE REMARK 999
Mse 680	Met 680	modified residue
Thr 697	Lys 697	SEE REMARK 999
Mse 702	Met 702	modified residue
Phe 794	Leu 794	SEE REMARK 999
Mse 969	Met 969	modified residue
Mse 996	Thr 996	engineered mutation
Mse 1005	Met 1005	modified residue
Mse 1015	Met 1015	modified residue

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	205992.1
Non-Polymers*	Number of molecules	10
	Total formula weight	1351.0
All*	Total formula weight	207343.1

*Water molecules are not included.