1X8V
Estriol-bound and ligand-free structures of sterol 14alpha-demethylase (CYP51)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cytochrome P450 51 | polymer | 455 | 51477.3 | 1 | UniProt (P0A512) Pfam (PF00067) UniProt (by SIFTS) (P9WPP9) | Mycobacterium tuberculosis | CYPLI, P450-LIA1, Sterol 14-alpha demethylase, Lanosterol 14-alpha demethylase, P450-14DM |
| 2 | B (A) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
| 3 | C, D (A) | ESTRIOL | non-polymer | 288.4 | 2 | Chemie (ESL) | |||
| 4 | E (A) | water | water | 18.0 | 319 | Chemie (HOH) |
Sequence modifications
A: 1 - 451 (UniProt: P0A512)
| PDB | External Database | Details |
|---|---|---|
| Leu 37 | Cys 37 | engineered mutation |
| Ala 442 | Cys 442 | engineered mutation |
| His 452 | - | expression tag |
| His 453 | - | expression tag |
| His 454 | - | expression tag |
| His 455 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 51477.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1193.2 | |
| All* | Total formula weight | 52670.5 |
