1X8V
Estriol-bound and ligand-free structures of sterol 14alpha-demethylase (CYP51)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cytochrome P450 51 | polymer | 455 | 51477.3 | 1 | UniProt (P0A512) Pfam (PF00067) UniProt (by SIFTS) (P9WPP9) | Mycobacterium tuberculosis | CYPLI, P450-LIA1, Sterol 14-alpha demethylase, Lanosterol 14-alpha demethylase, P450-14DM |
| 2 | B (A) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
| 3 | C, D (A) | ESTRIOL | non-polymer | 288.4 | 2 | Chemie (ESL) PubChem (16219315) PubChem (16394482) PubChem (16396546) PubChem (16757678) PubChem (17757252) PubChem (3269) PubChem (21252247) PubChem (22827173) PubChem (23616045) PubChem (5756) PubChem (25183077) PubChem (25319206) PubChem (40459112) PubChem (40469516) PubChem (40469517) PubChem (40488277) PubChem (40520500) PubChem (42051933) PubChem (44278835) PubChem (44358113) PubChem (68929) PubChem (21968805) PubChem (45934190) PubChem (46781459) PubChem (51397536) PubChem (51397537) PubChem (51397538) PubChem (51397539) PubChem (51417552) PubChem (52211004) PubChem (40469515) PubChem (57140169) PubChem (46781511) PubChem (68209949) PubChem (69116743) PubChem (52211003) PubChem (73265361) PubChem (667481) PubChem (719690) PubChem (76955639) PubChem (58992547) PubChem (932911) PubChem (932913) PubChem (932914) PubChem (968806) PubChem (256737) PubChem (5317223) PubChem (92259573) PubChem (92136238) PubChem (6918969) PubChem (9838894) PubChem (6432479) PubChem (92974167) PubChem (129010462) PubChem (131664366) PubChem (6604179) PubChem (7048596) PubChem (7060905) PubChem (9994296) PubChem (124423234) PubChem (11652194) PubChem (12309615) PubChem (126547580) PubChem (126969961) PubChem (133662447) PubChem (143489163) PubChem (162945557) PubChem (162945558) PubChem (162945559) PubChem (162945560) PubChem (171764558) PubChem (175979927) | |||
| 4 | E (A) | water | water | 18.0 | 319 | Chemie (HOH) |
Sequence modifications
A: 1 - 451 (UniProt: P0A512)
| PDB | External Database | Details |
|---|---|---|
| Leu 37 | Cys 37 | engineered mutation |
| Ala 442 | Cys 442 | engineered mutation |
| His 452 | - | expression tag |
| His 453 | - | expression tag |
| His 454 | - | expression tag |
| His 455 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 51477.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1193.2 | |
| All* | Total formula weight | 52670.5 |
