1WRK
Crystal structure of the N-terminal domain of human cardiac troponin C in complex with trifluoperazine (orthrombic crystal form)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Troponin C, slow skeletal and cardiac muscles | polymer | 88 | 9951.1 | 2 | UniProt (P63316) Pfam (PF13833) | Homo sapiens (human) | TN-C |
| 2 | C, F (A, B) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 3 | D, E, G, H (A, B) | 10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE | non-polymer | 407.5 | 4 | Chemie (TFP) | |||
| 4 | I, J (A, B) | water | water | 18.0 | 100 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 88 (UniProt: P63316)
| PDB | External Database | Details |
|---|---|---|
| Ser 35 | Cys 35 | engineered mutation |
| Ser 84 | Cys 84 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 19902.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1710.1 | |
| All* | Total formula weight | 21612.3 |
