1WBV
Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | MITOGEN-ACTIVATED PROTEIN KINASE 14 | polymer | 360 | 41343.2 | 1 | UniProt (Q16539) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | MITOGEN-ACTIVATED PROTEIN KINASE P38ALPHA, MAP KINASE P38ALPHA, CYTOKINE SUPPRESSIVE ANTI-INFLAMMATORY DRUG BINDING PROTEIN, CSAID BINDING PROTEIN, CSBP, MAX-INTERACTING PROTEIN 2, MAP KINASE MXI2, SAPK2A |
| 2 | B (A) | 3-FLUORO-N-1H-INDOL-5-YL-5-MORPHOLIN-4-YLBENZAMIDE | non-polymer | 339.4 | 1 | Chemie (LI3) | |||
| 3 | C, D, E (A) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 4 | F (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 5 | G (A) | water | water | 18.0 | 569 | Chemie (HOH) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41343.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 693.8 | |
| All* | Total formula weight | 42037.0 |
