1W6P
X-RAY CRYSTAL STRUCTURE OF C2S HUMAN GALECTIN-1 COMPLEXED WITH N- Acetyl-LACTOSAMINE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GALECTIN-1 | polymer | 134 | 14657.4 | 1 | UniProt (P09382) Pfam (PF00337) | HOMO SAPIENS (HUMAN) | BETA-GALACTOSIDE-BINDING LECTIN L-14-I, HPL, LACTOSE-BINDING LECTIN 1, S-LAC LECTIN 1, GALAPTIN, HBL |
| 2 | B (B) | GALECTIN-1 | polymer | 134 | 14641.4 | 1 | UniProt (P09382) Pfam (PF00337) | HOMO SAPIENS (HUMAN) | BETA-GALACTOSIDE-BINDING LECTIN L-14-I, HPL, LACTOSE-BINDING LECTIN 1, S-LAC LECTIN 1, GALAPTIN, HBL |
| 3 | C, D (C, D) | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose | branched | 383.3 | 2 | In PDB BIRD (PRD_900019) GlyTouCan (G79333MY) | N-acetyl-alpha-lactosamine | ||
| 4 | E, F, H, I, J (A, B) | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 5 | Chemie (BME) | |||
| 5 | G (B) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 6 | K, L (A, B) | water | water | 18.0 | 175 | Chemie (HOH) |
Sequence modifications
A: 1001 - 1134 (UniProt: P09382)
B: 2001 - 2134 (UniProt: P09382)
| PDB | External Database | Details |
|---|---|---|
| Ser 1002 | Cys 2 | engineered mutation |
| Asp 1065 | Gly 65 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 2002 | Cys 2 | engineered mutation |
| Asp 2065 | Gly 65 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29298.9 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 766.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 486.7 | |
| All* | Total formula weight | 30552.3 |
