1W6O

X-RAY CRYSTAL STRUCTURE OF C2S HUMAN GALECTIN-1 COMPLEXED WITH LACTOSE

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	GALECTIN-1	polymer	134	14657.4	1	UniProt (P09382) Pfam (PF00337) In PDB	HOMO SAPIENS (HUMAN)	BETA-GALACTOSIDE-BINDING LECTIN L-14-I, HPL, LACTOSE-BINDING LECTIN 1, S-LAC LECTIN 1, GALAPTIN, HBL
2	B	GALECTIN-1	polymer	134	14641.4	1	UniProt (P09382) Pfam (PF00337) In PDB	HOMO SAPIENS (HUMAN)	BETA-GALACTOSIDE-BINDING LECTIN L-14-I, HPL, LACTOSE-BINDING LECTIN 1, S-LAC LECTIN 1, GALAPTIN, HBL
3	C, D	beta-D-galactopyranose-(1-4)-beta-D-glucopyranose	branched		342.3	2	In PDB BIRD (PRD_900004) GlyTouCan (G84224TW)		beta-lactose
4	A, B	BETA-MERCAPTOETHANOL	non-polymer		78.1	5	Chemie (BME)
5	B	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
6		water	water		18.0	250	Chemie (HOH)

Sequence modifications

A: 1001 - 1134 (UniProt: P09382)

PDB	External Database	Details
Ser 1002	Cys 2	engineered mutation
Asp 1065	Gly 65	engineered mutation

B: 2001 - 2134 (UniProt: P09382)

PDB	External Database	Details
Ser 2002	Cys 2	engineered mutation
Asp 2065	Gly 65	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	29298.9
Branched	Number of molecules	2
	Total formula weight	684.6
Non-Polymers*	Number of molecules	6
	Total formula weight	486.7
All*	Total formula weight	30470.2

*Water molecules are not included.