1W1I
Crystal structure of dipeptidyl peptidase IV (DPPIV or CD26) in complex with adenosine deaminase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | DIPEPTIDYL PEPTIDASE IV | polymer | 728 | 84462.6 | 4 | UniProt (P27487) Pfam (PF00930) Pfam (PF00326) | HOMO SAPIENS (HUMAN) | DPP IV, T-CELL ACTIVATION ANTIGEN CD26, TP103, ADENOSINE DEAMINASE COMPLEXING PROTEIN-2, ADABP |
| 2 | E, F, G, H (E, F, G, H) | ADENOSINE DEAMINASE | polymer | 357 | 40457.9 | 4 | UniProt (P56658) Pfam (PF00962) | BOS TAURUS (BOVINE) | ADENOSINE AMINOHYDROLASE |
| 3 | I, Q (I, Q) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 2 | In PDB GlyTouCan (G21290RB) | |||
| 4 | J, K, N, P, R... (J, K, N, P, R...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 9 | In PDB GlyTouCan (G42666HT) | |||
| 5 | L, O, T, X (L, O, T, X) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 4 | In PDB GlyTouCan (G81315DD) | |||
| 6 | M, V (M, V) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 2 | In PDB GlyTouCan (G86851RC) | |||
| 7 | AA, BA, CA, DA, EA... (A, B, C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 15 | Chemie (NAG) | |||
| 8 | OA, PA, QA, RA (E, F, G, H) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) |
Sequence modifications
E, F, G, H: 1 - 357 (UniProt: P56658)
| PDB | External Database | Details |
|---|---|---|
| Asp 8 | Asn 7 | conflict |
| Lys 32 | Arg 31 | conflict |
| Arg 33 | Lys 32 | conflict |
| Leu 47 | Gln 46 | conflict |
| Thr 57 | Ser 56 | conflict |
| Asp 60 | Glu 59 | conflict |
| Asp 77 | Glu 76 | conflict |
| Ile 79 | Val 78 | conflict |
| Gln 199 | Lys 198 | variant |
| Thr 246 | Ala 245 | variant |
| Ile 261 | Val 260 | conflict |
| Ala 279 | Pro 278 | conflict |
| Ile 281 | Val 280 | conflict |
| Lys 313 | Asn 312 | conflict |
| Asp 314 | Glu 313 | conflict |
| Arg 352 | Gly 351 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 499682.1 | |
| Branched | Number of molecules | 17 |
| Total formula weight | 8690.1 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 3579.8 | |
| All* | Total formula weight | 511951.9 |
