1V40
First Inhibitor Complex Structure of Human Hematopoietic Prostaglandin D Synthase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Glutathione-requiring prostaglandin D synthase | polymer | 198 | 23256.7 | 4 | UniProt (O60760) Pfam (PF02798) Pfam (PF14497) | Homo sapiens (human) | Glutathione-dependent PGD synthetase, Prostaglandin-H2 D-isomerase, Hematopoietic prostaglandin D synthase, H-PGDS |
| 2 | E, J (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | F, K, N, R (A, B, C, D) | GLUTATHIONE | non-polymer | 307.3 | 4 | Chemie (GSH) | |||
| 4 | G, L, O, S (A, B, C, D) | 3-(1,3-BENZOTHIAZOL-2-YL)-2-(1,4-DIOXO-1,2,3,4-TETRAHYDROPHTHALAZIN-6-YL)-5-[(E)-2-PHENYLVINYL]-3H-TETRAAZOL-2-IUM | non-polymer | 466.5 | 4 | Chemie (O16) | |||
| 5 | H, I, M, P, Q... (A, B, C, D) | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 6 | U, V, W, X (A, B, C, D) | water | water | 18.0 | 1462 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 2 - 199 (UniProt: O60760)
| PDB | External Database | Details |
|---|---|---|
| Met 144 | Asn 143 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 93026.9 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 3696.4 | |
| All* | Total formula weight | 96723.4 |
