1UNL
Structural mechanism for the inhibition of CD5-p25 from the roscovitine, aloisine and indirubin.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | CYCLIN-DEPENDENT KINASE 5 | polymer | 292 | 33349.5 | 2 | UniProt (Q00535) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | TAU PROTEIN KINASE II CATALYTIC SUBUNIT, TPKII CATALYTIC SUBUNIT, SERINE/THREONINE PROTEIN KINASE PSSALRE |
| 2 | C, D (D, E) | CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 | polymer | 208 | 23200.7 | 2 | UniProt (Q15078) Pfam (PF03261) | HOMO SAPIENS (HUMAN) | CDK5 ACTIVATOR 1, CYCLIN-DEPENDENT KINASE 5 REGULATORY SUBUNIT 1, TAU PROTEIN KINASE II, TPKII REGULATORY SUBUNIT, P23, P25, P35, P25NCK5A |
| 3 | E (A) | R-ROSCOVITINE | non-polymer | 354.4 | 1 | Chemie (RRC) | |||
| 4 | F, G, H, I (A, B, D, E) | water | water | 18.0 | 302 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 292 (UniProt: Q00535)
| PDB | External Database | Details |
|---|---|---|
| Asn 144 | Asp 144 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 113100.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 354.4 | |
| All* | Total formula weight | 113454.8 |
