1UKI

Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	mitogen-activated protein kinase 8 isoform 4	polymer	369	42588.2	1	UniProt (P45983) Pfam (PF00069) In PDB	Homo sapiens (human)	JNK1
2	B	11-mer peptide from C-jun-amino-terminal kinase interacting protein 1	polymer	11	1345.6	1	UniProt (Q9WVI9) In PDB		JIP1
3	A	2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE	non-polymer		220.2	1	Chemie (537)
4		water	water		18.0	15	Chemie (HOH)

Sequence modifications

A: 1 - 363 (UniProt: P45983)

PDB	External Database	Details
His 364	-	expression tag
His 365	-	expression tag
His 366	-	expression tag
His 367	-	expression tag
His 368	-	expression tag
His 369	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	43933.8
Non-Polymers*	Number of molecules	1
	Total formula weight	220.2
All*	Total formula weight	44154.0

*Water molecules are not included.