1UK0

Crystal structure of catalytic domain of human poly(ADP-ribose) polymerase with a novel inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Poly [ADP-ribose] polymerase-1	polymer	350	39196.9	2	UniProt (P09874) Pfam (PF02877) Pfam (PF00644)	Homo sapiens (human)	poly(ADP-ribose) polymerase, PARP-1, ADPRT, NAD(+) ADP-ribosyltransferase-1, Poly[ADP-ribose] synthetase-1
2	C, D (A, B)	2-{3-[4-(4-FLUOROPHENYL)-3,6-DIHYDRO-1(2H)-PYRIDINYL]PROPYL}-8-METHYL-4(3H)-QUINAZOLINONE	non-polymer		377.5	2	Chemie (FRM)
3	E, F (A, B)	water	water		18.0	253	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	78393.7
Non-Polymers*	Number of molecules	2
	Total formula weight	754.9
All*	Total formula weight	79148.6

*Water molecules are not included.