1U71
Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase Ternary Crystal Complexes with Methotrexate and NADPH
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Dihydrofolate reductase | polymer | 186 | 21393.6 | 1 | UniProt (P00374) Pfam (PF00186) In PDB | Homo sapiens (human) | |
2 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
3 | A | 6-(2,5-DIMETHOXY-BENZYL)-5-METHYL-PYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE | non-polymer | 325.4 | 1 | Chemie (MXA) | |||
4 | water | water | 18.0 | 68 | Chemie (HOH) |
Sequence modifications
A: 1 - 186 (UniProt: P00374)
PDB | External Database | Details |
---|---|---|
Arg 22 | Leu 22 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 21393.6 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 517.5 | |
All* | Total formula weight | 21911.1 |