1U70
Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dihydrofolate reductase | polymer | 186 | 21547.9 | 1 | UniProt (P00375) Pfam (PF00186) | Mus musculus (house mouse) | |
| 2 | B (A) | METHOTREXATE | non-polymer | 454.4 | 1 | Chemie (MTX) | |||
| 3 | C (A) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 4 | D (A) | water | water | 18.0 | 27 | Chemie (HOH) |
Sequence modifications
A: 1 - 186 (UniProt: P00375)
| PDB | External Database | Details |
|---|---|---|
| Arg 22 | Leu 22 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 21547.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1199.9 | |
| All* | Total formula weight | 22747.7 |
