1TTV
NMR Structure of a Complex Between MDM2 and a Small Molecule Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Ubiquitin-protein ligase E3 Mdm2 | polymer | 107 | 12206.9 | 1 | UniProt (P56273) Pfam (PF02201) In PDB | Xenopus laevis (African clawed frog) | p53-binding protein Mdm2, Double minute 2 protein, Xdm2 |
| 2 | A | 1-{[4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXYPHENYL)-4,5-DIHYDRO-1H-IMIDAZOL-1-YL]CARBONYL}PIPERAZINE | non-polymer | 567.5 | 1 | Chemie (IMY) |
Sequence modifications
A: 13 - 119 (UniProt: P56273)
| PDB | External Database | Details |
|---|---|---|
| Leu 50 | Ile 50 | engineered mutation |
| His 92 | Pro 92 | engineered mutation |
| Ile 95 | Leu 95 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 12206.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 567.5 | |
| All* | Total formula weight | 12774.4 |
