1TLO
High resolution crystal structure of calpain I protease core in complex with E64
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Calpain 1, large [catalytic] subunit | polymer | 339 | 38804.6 | 1 | UniProt (P97571) Pfam (PF00648) | Rattus norvegicus (Norway rat) | Calcium-activated neutral proteinase, CANP, Mu-type, muCANP, Micromolar-calpain |
| 2 | B, C (A) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 3 | D (A) | N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE | non-polymer | 360.4 | 1 | Chemie (E64) | |||
| 4 | E (A) | water | water | 18.0 | 53 | Chemie (HOH) |
Sequence modifications
A: 27 - 356 (UniProt: P97571)
| PDB | External Database | Details |
|---|---|---|
| Met 26 | - | initiating methionine |
| Leu 357 | - | expression tag |
| Glu 358 | - | expression tag |
| His 359 | - | expression tag |
| His 360 | - | expression tag |
| His 361 | - | expression tag |
| His 362 | - | expression tag |
| His 363 | - | expression tag |
| His 364 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38804.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 440.6 | |
| All* | Total formula weight | 39245.1 |
