1TLO
High resolution crystal structure of calpain I protease core in complex with E64
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Calpain 1, large [catalytic] subunit | polymer | 339 | 38804.6 | 1 | UniProt (P97571) Pfam (PF00648) In PDB | Rattus norvegicus (Norway rat) | Calcium-activated neutral proteinase, CANP, Mu-type, muCANP, Micromolar-calpain |
2 | A | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
3 | A | N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE | non-polymer | 360.4 | 1 | Chemie (E64) | |||
4 | water | water | 18.0 | 53 | Chemie (HOH) |
Sequence modifications
A: 27 - 356 (UniProt: P97571)
PDB | External Database | Details |
---|---|---|
Met 26 | - | initiating methionine |
Leu 357 | - | expression tag |
Glu 358 | - | expression tag |
His 359 | - | expression tag |
His 360 | - | expression tag |
His 361 | - | expression tag |
His 362 | - | expression tag |
His 363 | - | expression tag |
His 364 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 38804.6 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 440.6 | |
All* | Total formula weight | 39245.1 |