1T9R

Catalytic Domain Of Human Phosphodiesterase 5A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	cGMP-specific 3',5'-cyclic phosphodiesterase	polymer	366	42109.3	1	UniProt (O76074) Pfam (PF00233) In PDB	Homo sapiens (human)	CGB-PDE, cGMP-binding cGMP-specific phosphodiesterase
2	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
3	A	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
4	A	CITRIC ACID	non-polymer		192.1	1	Chemie (CIT)
5		water	water		18.0	90	Chemie (HOH)

Sequence modifications

A: 531 - 875 (UniProt: O76074)

PDB	External Database	Details
Met 510	-	expression tag
Gly 511	-	expression tag
Ser 512	-	expression tag
Ser 513	-	expression tag
His 514	-	expression tag
His 515	-	expression tag
His 516	-	expression tag
His 517	-	expression tag
His 518	-	expression tag
His 519	-	expression tag
Ser 520	-	expression tag
Ser 521	-	expression tag
Gly 522	-	expression tag
Leu 523	-	expression tag
Val 524	-	expression tag
Pro 525	-	expression tag
Arg 526	-	expression tag
Gly 527	-	expression tag
Ser 528	-	expression tag
His 529	-	expression tag
Met 530	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	42109.3
Non-Polymers*	Number of molecules	3
	Total formula weight	352.5
All*	Total formula weight	42461.8

*Water molecules are not included.