1T67
Crystal Structure of Human HDAC8 complexed with MS-344
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone deacetylase 8 | polymer | 377 | 41802.5 | 1 | UniProt (Q9BY41) Pfam (PF00850) | Homo sapiens (human) | HDAC8 |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C, D (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 4 | E (A) | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide | non-polymer | 307.4 | 1 | Chemie (B3N) | |||
| 5 | F (A) | water | water | 18.0 | 137 | Chemie (HOH) |
Sequence modifications
A: 1 - 377 (UniProt: Q9BY41)
| PDB | External Database | Details |
|---|---|---|
| Leu 31 | Pro 31 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41802.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 418.8 | |
| All* | Total formula weight | 42221.3 |
