1T46
STRUCTURAL BASIS FOR THE AUTOINHIBITION AND STI-571 INHIBITION OF C-KIT TYROSINE KINASE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | polymer | 313 | 35388.9 | 1 | UniProt (P10721) GenBank (4557695) Pfam (PF07714) In PDB | Homo sapiens (human) | |
| 2 | A | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 3 | A | 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE | non-polymer | 493.6 | 1 | Chemie (STI) | |||
| 4 | water | water | 18.0 | 268 | Chemie (HOH) |
Sequence modifications
A: 565 - 693 (UniProt: P10721)
A: 754 - 935 (GenBank: 4557695)
| PDB | External Database | Details |
|---|---|---|
| Thr 694 | - | see remark 999 |
| Ser 753 | - | see remark 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35388.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 683.5 | |
| All* | Total formula weight | 36072.5 |
