1T44
Structural basis of actin sequestration by thymosin-B4: Implications for arp2/3 activation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (G) | Chimera of Gelsolin domain 1 and C-Terminal domain of thymosin Beta-4 | polymer | 147 | 16632.5 | 1 | UniProt (P06396) UniProt (P20065) Pfam (PF00626) | Homo sapiens (human house mouse) | |
| 2 | B (A) | Actin, alpha | polymer | 370 | 41273.1 | 1 | UniProt (P02568) Pfam (PF00022) UniProt (by SIFTS) (P68135) | Oryctolagus cuniculus (rabbit) | Alpha-actin 1 |
| 3 | C, D, E (G, A) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 4 | F (A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 5 | G, H (G, A) | water | water | 18.0 | 427 | Chemie (HOH) |
Sequence modifications
G: 28 - 152 (UniProt: P06396)
G: 153 - 171 (UniProt: P20065)
| PDB | External Database | Details |
|---|---|---|
| Gly 25 | - | cloning artifact |
| Ser 26 | - | cloning artifact |
| His 27 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 57905.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 627.4 | |
| All* | Total formula weight | 58533.1 |
