1T2E
Plasmodium falciparum lactate dehydrogenase S245A, A327P mutant complexed with NADH and oxamate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | L-lactate dehydrogenase | polymer | 322 | 34987.6 | 1 | UniProt (Q27743) | Plasmodium falciparum (malaria parasite P. falciparum) | LDH-P |
| 2 | B (A) | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE | non-polymer | 665.4 | 1 | Chemie (NAI) PubChem (16219774) PubChem (928) PubChem (44119956) PubChem (44415182) PubChem (439153) PubChem (124934832) PubChem (126455899) PubChem (94865921) PubChem (94865923) PubChem (134693949) PubChem (12309339) PubChem (12309347) PubChem (124432988) PubChem (140875346) PubChem (11250888) PubChem (12309341) PubChem (124934831) PubChem (124934833) PubChem (162951601) PubChem (162951600) PubChem (164575491) PubChem (169545638) PubChem (170905224) PubChem (174316169) PubChem (129607000) PubChem (129628338) PubChem (146167236) PubChem (162951602) PubChem (174084875) | |||
| 3 | C (A) | OXAMIC ACID | non-polymer | 89.0 | 1 | Chemie (OXM) PubChem (974) | |||
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 5 | E (A) | water | water | 18.0 | 242 | Chemie (HOH) |
Sequence modifications
A: 17 - 329 (UniProt: Q27743)
| PDB | External Database | Details |
|---|---|---|
| Ala 245 | Ser 234 | engineered mutation |
| Pro 327 | Ala 314 | engineered mutation |
| His 330 | - | expression tag |
| His 331 | - | expression tag |
| His 332 | - | expression tag |
| His 333 | - | expression tag |
| His 334 | - | expression tag |
| His 335 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34987.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 846.6 | |
| All* | Total formula weight | 35834.2 |
