1T0P
Structural Basis of ICAM recognition by integrin alpahLbeta2 revealed in the complex structure of binding domains of ICAM-3 and alphaLbeta2 at 1.65 A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Integrin alpha-L | polymer | 175 | 19911.7 | 1 | UniProt (P20701) Pfam (PF00092) | Homo sapiens (human) | cell surface glycoprotein CD11a; antigen CD11A (p180); lymphocyte function-associated antigen 1; CD11a |
| 2 | B (B) | Intercellular adhesion molecule-3 | polymer | 86 | 9025.1 | 1 | UniProt (P32942) Pfam (PF03921) | Homo sapiens (human) | ICAM-3; ICAM-R; CDw50; CD50 antigen |
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D, E (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 169 | Chemie (HOH) |
Sequence modifications
A: 128 - 301 (UniProt: P20701)
| PDB | External Database | Details |
|---|---|---|
| Met 127 | - | initiating methionine |
| Cys 287 | Lys 312 | engineered mutation |
| Cys 294 | Lys 319 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28936.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 466.7 | |
| All* | Total formula weight | 29403.5 |
