1T03

HIV-1 reverse transcriptase crosslinked to tenofovir terminated template-primer (complex P)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	T	Synthetic oligonucleotide template	polymer	27	8367.4	1
2	P	Synthetic oligonucleotide primer	polymer	21	6430.3	1
3	A	POL polyprotein	polymer	558	64249.7	1	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB	Human immunodeficiency virus 1
4	B	POL polyprotein	polymer	437	51095.6	1	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB	Human immunodeficiency virus 1
5	L	monoclonal antibody light chain	polymer	211	23362.7	1		Mus musculus (house mouse)
6	H	monoclonal antibody heavy chain	polymer	225	24000.8	1		Mus musculus (house mouse)
7	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)

Sequence modifications

A: 1 - 558 (UniProt: P03366)

PDB	External Database	Details
Cys 258	Gln 425	engineered mutation
Ser 280	Cys 447	engineered mutation

B: 1 - 429 (UniProt: P03366)

PDB	External Database	Details
Ser 280	Cys 447	engineered mutation
Gly 430	-	cloning artifact
Gly 431	-	cloning artifact
His 432	-	expression tag
His 433	-	expression tag
His 434	-	expression tag
His 435	-	expression tag
His 436	-	expression tag
His 437	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	177506.4
Non-Polymers*	Number of molecules	1
	Total formula weight	24.3
All*	Total formula weight	177530.7

*Water molecules are not included.