1SZC
Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD+-dependent Sir2 histone/protein deacetylases
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | NAD-dependent deacetylase HST2 | polymer | 297 | 33476.4 | 1 | UniProt (P53686) Pfam (PF02146) In PDB | Saccharomyces cerevisiae (baker's yeast) | Homologous to SIR2 protein 2 |
2 | B | Histone H4 peptide | polymer | 10 | 1197.5 | 1 | UniProt (P02309) In PDB | ||
3 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
4 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
5 | A | CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 662.5 | 1 | Chemie (CNA) | |||
6 | A | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
7 | water | water | 18.0 | 293 | Chemie (HOH) |
Sequence modifications
A: 1 - 294 (UniProt: P53686)
B: 12 - 21 (UniProt: P02309)
PDB | External Database | Details |
---|---|---|
Met -2 | - | expression tag |
Ala -1 | - | expression tag |
Ser 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Aly 16 | Lys 16 | modified residue |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 34673.8 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1131.7 | |
All* | Total formula weight | 35805.5 |