1SZC
Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD+-dependent Sir2 histone/protein deacetylases
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NAD-dependent deacetylase HST2 | polymer | 297 | 33476.4 | 1 | UniProt (P53686) Pfam (PF02146) | Saccharomyces cerevisiae (baker's yeast) | Homologous to SIR2 protein 2 |
| 2 | B (B) | Histone H4 peptide | polymer | 10 | 1197.5 | 1 | UniProt (P02309) | ||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | E (A) | CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 662.5 | 1 | Chemie (CNA) | |||
| 6 | F, G, H, I (A) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 7 | J, K (A, B) | water | water | 18.0 | 293 | Chemie (HOH) |
Sequence modifications
A: 1 - 294 (UniProt: P53686)
B: 12 - 21 (UniProt: P02309)
| PDB | External Database | Details |
|---|---|---|
| Met -2 | - | expression tag |
| Ala -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Aly 16 | Lys 16 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 34673.8 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1131.7 | |
| All* | Total formula weight | 35805.5 |
