1SVG
Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 4
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | cAMP-dependent protein kinase, alpha-catalytic subunit | polymer | 350 | 40786.4 | 1 | UniProt (P00517) Pfam (PF00069) In PDB | Bos taurus (cattle) | PKA C-alpha, PROTEIN KINASE A |
2 | B | CAMP-DEPENDENT PROTEIN KINASE INHIBITOR, ALPHA FORM | polymer | 20 | 2226.4 | 1 | UniProt (P04541) UniProt (by SIFTS) (P61926) In PDB | PKI-alpha, cAMP-dependent protein kinase inhibitor, muscle/brain isoform | |
3 | A | N-{(3R,4R)-4-[4-(2-FLUORO-6-HYDROXY-3-METHOXY-BENZOYL)-BENZOYLAMINO]-AZEPAN-3-YL}ISONICOTINAMIDE | non-polymer | 506.5 | 1 | Chemie (I04) | |||
4 | water | water | 18.0 | 121 | Chemie (HOH) |
Sequence modifications
A: 1 - 350 (UniProt: P00517)
PDB | External Database | Details |
---|---|---|
Sep 10 | Ser 10 | MODIFIED RESIDUE |
Tpo 197 | Thr 197 | MODIFIED RESIDUE |
Sep 338 | Ser 338 | MODIFIED RESIDUE |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 43012.8 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 506.5 | |
All* | Total formula weight | 43519.3 |