1SMH
Protein kinase A variant complex with completely ordered N-terminal helix
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | cAMP-Dependent Protein Kinase, alpha-catalytic subunit | polymer | 350 | 40663.4 | 1 | UniProt (P00517) Pfam (PF00069) | Bos taurus (cattle) | PKA C-alpha |
| 2 | B (B) | cAMP-dependent protein kinase inhibitor, alpha form | polymer | 20 | 2226.4 | 1 | UniProt (P04541) UniProt (by SIFTS) (P61926) | PKI-alpha; cAMP-dependent protein kinase inhibitor, muscle/brain isoform; protein kinase inhibitor alpha | |
| 3 | C, D, E, F, G... (A, B) | (R,R)-2,3-BUTANEDIOL | non-polymer | 90.1 | 6 | Chemie (BU3) | |||
| 4 | H (A) | N-OCTANOYL-N-METHYLGLUCAMINE | non-polymer | 321.4 | 1 | Chemie (MG8) | |||
| 5 | J, K (A, B) | water | water | 18.0 | 175 | Chemie (HOH) |
Sequence modifications
A: 1 - 350 (UniProt: P00517)
| PDB | External Database | Details |
|---|---|---|
| Glu 84 | Gln 84 | engineered mutation |
| Ala 123 | Val 123 | engineered mutation |
| Met 173 | Leu 173 | engineered mutation |
| Leu 187 | Phe 187 | engineered mutation |
| Tpo 197 | Thr 197 | modified residue |
| Sep 338 | Ser 338 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42889.8 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 862.1 | |
| All* | Total formula weight | 43751.9 |
