1SHL

CASPASE-7 IN COMPLEX WITH FICA ALLOSTERIC INHIBITOR

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Caspase-7	polymer	245	28118.1	2	UniProt (P55210) Pfam (PF00656)	Homo sapiens (human)	ICE-like apoptotic protease 3, ICE-LAP3, Apoptotic protease Mch-3, CMH-1
2	C, D (A, B)	5-FLUORO-1H-INDOLE-2-CARBOXYLIC ACID-(2-MERCAPTO-ETHYL)-AMIDE	non-polymer		238.3	2	Chemie (FXN)

Sequence modifications

A, B: 57 - 199 (UniProt: P55210)

PDB	External Database	Details
Ala 192	Asp 192	engineered mutation
Gln 304	-	expression tag
Leu 305	-	expression tag
His 306	-	expression tag
His 307	-	expression tag
His 308	-	expression tag
His 309	-	expression tag
His 310	-	expression tag
His 311	-	expression tag

A, B: 210 - 303 (UniProt: P55210)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	56236.1
Non-Polymers*	Number of molecules	2
	Total formula weight	476.6
All*	Total formula weight	56712.7

*Water molecules are not included.