1S6P
CRYSTAL STRUCTURE OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R100943
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | POL polyprotein [Contains: Reverse transcriptase] | polymer | 560 | 64501.0 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | Human immunodeficiency virus 1 | HIV-1 RT |
| 2 | B (B) | POL polyprotein [Contains: Reverse transcriptase] | polymer | 430 | 50281.8 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) | Human immunodeficiency virus 1 | HIV-1 RT |
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (A) | 1-(4-CYANO-PHENYL)-3-[2-(2,6-DICHLORO-PHENYL)-1-IMINO-ETHYL]-THIOUREA | non-polymer | 363.3 | 1 | Chemie (IET) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 151 | Chemie (HOH) |
Sequence modifications
A: 1 - 560 (UniProt: P03366)
B: 1 - 430 (UniProt: P03366)
| PDB | External Database | Details |
|---|---|---|
| Ser 280 | Cys 447 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 280 | Cys 447 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 114782.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 387.6 | |
| All* | Total formula weight | 115170.3 |
