1S3U
Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Dihydrofolate reductase | polymer | 186 | 21349.5 | 1 | UniProt (P00374) Pfam (PF00186) In PDB | Homo sapiens (human) | |
| 2 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 3 | A | (2R,6S)-6-{[methyl(3,4,5-trimethoxyphenyl)amino]methyl}-1,2,5,6,7,8-hexahydroquinazoline-2,4-diamine | non-polymer | 375.5 | 1 | Chemie (TQD) | |||
| 4 | water | water | 18.0 | 52 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 21349.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 567.6 | |
| All* | Total formula weight | 21917.1 |
