1S0X

Crystal structure of the human RORalpha ligand binding domain in complex with cholesterol sulfate at 2.2A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Nuclear receptor ROR-alpha	polymer	270	31514.3	1	UniProt (P35398) Pfam (PF00104)	Homo sapiens (human)	Nuclear receptor RZR-alpha
2	B (A)	CHOLEST-5-EN-3-YL HYDROGEN SULFATE	non-polymer		466.7	1	Chemie (C3S) PubChem (18631913) PubChem (18637921) PubChem (65076) PubChem (25055661) PubChem (34174273) PubChem (44359124) PubChem (34174265) PubChem (46936278) PubChem (52934309) PubChem (53683001) PubChem (4259412) PubChem (86318757) PubChem (86318759) PubChem (86318761) PubChem (9847391) PubChem (86310857) PubChem (87292651) PubChem (11969852) PubChem (14189346) PubChem (99569635) PubChem (124301052) PubChem (117705488) PubChem (122130877) PubChem (123134861) PubChem (124225017) PubChem (124225018) PubChem (124225019) PubChem (124904518) PubChem (124904519) PubChem (131697794) PubChem (146156788) PubChem (146460988) PubChem (137705228) PubChem (139468493) PubChem (146663698) PubChem (163452773) PubChem (169650022)
3	C (A)	water	water		18.0	256	Chemie (HOH)

Sequence modifications

A: 271 - 523 (UniProt: P35398)

PDB	External Database	Details
Gly 254	-	cloning artifact
Ser 255	-	cloning artifact
Ser 256	-	cloning artifact
His 257	-	expression tag
His 258	-	expression tag
His 259	-	expression tag
His 260	-	expression tag
His 261	-	expression tag
His 262	-	expression tag
Leu 263	-	expression tag
Glu 264	-	expression tag
Val 265	-	expression tag
Leu 266	-	expression tag
Phe 267	-	expression tag
Gln 268	-	expression tag
Gly 269	-	expression tag
Pro 270	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	31514.3
Non-Polymers*	Number of molecules	1
	Total formula weight	466.7
All*	Total formula weight	31981.0

*Water molecules are not included.