1RX6
DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH 5,10-DIDEAZATETRAHYDROFOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DIHYDROFOLATE REDUCTASE | polymer | 159 | 18020.3 | 1 | UniProt (P0ABQ4) Pfam (PF00186) | Escherichia coli | DHFR |
| 2 | B (A) | 5,10-DIDEAZATETRAHYDROFOLIC ACID | non-polymer | 443.5 | 1 | Chemie (DDF) | |||
| 3 | C (A) | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 1 | Chemie (BME) | |||
| 4 | D (A) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
| 5 | E (A) | water | water | 18.0 | 72 | Chemie (HOH) |
Sequence modifications
A: 1 - 159 (UniProt: P0ABQ4)
| PDB | External Database | Details |
|---|---|---|
| Asp 37 | Asn 37 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 18020.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1265.0 | |
| All* | Total formula weight | 19285.3 |
