1ROR

CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH AMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	polymer	378	43451.9	2	UniProt (Q07343) Pfam (PF00233)	Homo sapiens (human)	DPDE4, PDE32
2	C, D, F, G (A, B)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
3	E, H (A, B)	ADENOSINE MONOPHOSPHATE	non-polymer		347.2	2	Chemie (AMP)
4	I, J (A, B)	water	water		18.0	399	Chemie (HOH)

Sequence modifications

A, B: 152 - 528 (UniProt: Q07343)

PDB	External Database	Details
Met 151	-	initiating methionine
Ala 487	Ser 659	engineered mutation
Ala 489	Ser 661	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	86903.7
Non-Polymers*	Number of molecules	6
	Total formula weight	956.1
All*	Total formula weight	87859.8

*Water molecules are not included.