1RKG
crystal structure of the rat vitamin D receptor ligand binding domain complexed with 2MbisP and a synthetic peptide containing the NR2 box of DRIP 205
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Vitamin D3 receptor | polymer | 292 | 32983.7 | 1 | UniProt (P13053) Pfam (PF00104) | Rattus norvegicus (Norway rat) | VDR, 1,25-dihydroxyvitamin D3 receptor |
| 2 | B (C) | Peroxisome proliferator-activated receptor binding protein | polymer | 13 | 1570.9 | 1 | UniProt (Q15648) | PBP, PPAR binding protein, Thyroid hormone receptor-associated protein complex 220 kDa component, Trap220, Thyroid receptor interacting protein 2, TRIP2, p53 regulatory protein RB18A, Vitamin D receptor-interacting protein complex component DRIP205, Activator-recruited cofactor 205 kDa component, ARC205 | |
| 3 | C (A) | 5-{2-[1-(1-METHYL-PROPYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-2-METHYLENE-CYCLOHEXANE-1,3-DIOL | non-polymer | 344.5 | 1 | Chemie (VD1) PubChem (21158897) PubChem (25013229) PubChem (25013402) PubChem (44149908) PubChem (46937175) PubChem (58846974) PubChem (60011509) PubChem (5289547) PubChem (143234299) PubChem (72443215) PubChem (89279694) PubChem (90912484) PubChem (91039639) PubChem (91051789) PubChem (91274396) PubChem (91328502) PubChem (91408742) PubChem (91480016) PubChem (91526826) PubChem (10308866) PubChem (89143217) PubChem (11359904) PubChem (11602638) PubChem (143056407) PubChem (143831321) PubChem (163911477) | |||
| 4 | D, E (A, C) | water | water | 18.0 | 125 | Chemie (HOH) |
Sequence modifications
A: 116 - 423 (UniProt: P13053)
| PDB | External Database | Details |
|---|---|---|
| - | Ser 165 | deletion |
| - | Tyr 166 | deletion |
| - | Ser 167 | deletion |
| - | Pro 168 | deletion |
| - | Arg 169 | deletion |
| - | Pro 170 | deletion |
| - | Thr 171 | deletion |
| - | Leu 172 | deletion |
| - | Ser 173 | deletion |
| - | Phe 174 | deletion |
| - | Ser 175 | deletion |
| - | Gly 176 | deletion |
| - | Asn 177 | deletion |
| - | Ser 178 | deletion |
| - | Ser 179 | deletion |
| - | Ser 180 | deletion |
| - | Ser 181 | deletion |
| - | Ser 182 | deletion |
| - | Ser 183 | deletion |
| - | Asp 184 | deletion |
| - | Leu 185 | deletion |
| - | Tyr 186 | deletion |
| - | Thr 187 | deletion |
| - | Thr 188 | deletion |
| - | Ser 189 | deletion |
| - | Leu 190 | deletion |
| - | Asp 191 | deletion |
| - | Met 192 | deletion |
| - | Met 193 | deletion |
| - | Glu 194 | deletion |
| - | Pro 195 | deletion |
| - | Ser 196 | deletion |
| - | Gly 197 | deletion |
| - | Phe 198 | deletion |
| - | Ser 199 | deletion |
| - | Asn 200 | deletion |
| - | Leu 201 | deletion |
| - | Asp 202 | deletion |
| - | Leu 203 | deletion |
| - | Asn 204 | deletion |
| - | Gly 205 | deletion |
| - | Glu 206 | deletion |
| - | Asp 207 | deletion |
| - | Ser 208 | deletion |
| - | Asp 209 | deletion |
| - | Asp 210 | deletion |
| - | Pro 211 | deletion |
| Leu 424 | - | cloning artifact |
| Val 425 | - | cloning artifact |
| Pro 426 | - | cloning artifact |
| Arg 427 | - | cloning artifact |
| Gly 428 | - | cloning artifact |
| Ser 429 | - | cloning artifact |
| Met 430 | - | cloning artifact |
| Ala 431 | - | cloning artifact |
| Ile 432 | - | cloning artifact |
| Ser 433 | - | cloning artifact |
| Asp 434 | - | cloning artifact |
| Pro 435 | - | cloning artifact |
| Asn 436 | - | cloning artifact |
| Ser 437 | - | cloning artifact |
| Ser 438 | - | cloning artifact |
| Ser 439 | - | cloning artifact |
| Val 440 | - | cloning artifact |
| Asp 441 | - | cloning artifact |
| Lys 442 | - | cloning artifact |
| Leu 443 | - | cloning artifact |
| Ala 444 | - | cloning artifact |
| Ala 445 | - | cloning artifact |
| Ala 446 | - | cloning artifact |
| Leu 447 | - | cloning artifact |
| Glu 448 | - | cloning artifact |
| His 449 | - | expression tag |
| His 450 | - | expression tag |
| His 451 | - | expression tag |
| His 452 | - | expression tag |
| His 453 | - | expression tag |
| His 454 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 34554.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 344.5 | |
| All* | Total formula weight | 34899.2 |
