1RHM
CRYSTAL STRUCTURE OF THE COMPLEX OF CASPASE-3 WITH A NICOTINIC ACID ALDEHYDE INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | CASP-3 | polymer | 147 | 16639.9 | 2 | UniProt (P42574) Pfam (PF00656) | Homo sapiens (human) | Cysteine protease CPP32, Yama protein, CPP-32, Caspase-3, Apopain, SREBP cleavage activity 1, SCA-1 |
| 2 | B, D (B, D) | CASP-3 | polymer | 102 | 11910.6 | 2 | UniProt (P42574) Pfam (PF00656) | Homo sapiens (human) | Cysteine protease CPP32, Yama protein, CPP-32, Caspase-3, Apopain, SREBP cleavage activity 1, SCA-1 |
| 3 | E, F (A, C) | 4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID | non-polymer | 342.3 | 2 | Chemie (NA4) | |||
| 4 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 167 | Chemie (HOH) |
Sequence modifications
B, D: 310 - 402 (UniProt: P42574)
| PDB | External Database | Details |
|---|---|---|
| Glu 324 | Asp 190 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 57101.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 684.6 | |
| All* | Total formula weight | 57785.6 |
