1RD3
2.5A Structure of Anticoagulant Thrombin Variant E217K
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Prothrombin | polymer | 36 | 4096.5 | 2 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | Coagulation factor II |
| 2 | B, D (B, D) | Prothrombin | polymer | 259 | 29780.3 | 2 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | Coagulation factor II |
| 3 | E (E) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 894.8 | 1 | In PDB GlyTouCan (G89753YM) | |||
| 4 | F (F) | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G19870TQ) | |||
| 5 | G, H, N (B, D) | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) | |||
| 6 | I, J, K, L, M... (B, D) | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 7 | P, Q, R, S (A, B, C, D) | water | water | 18.0 | 44 | Chemie (HOH) |
Sequence modifications
B, D: 16 - 247 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Lys 145 | Glu 592 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 67753.6 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1465.4 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 837.5 | |
| All* | Total formula weight | 70056.5 |
